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Acacia catechu Willd. and Acacia arabica Willd. decrease the extent of anxiety behavior by reducing oxidative stress
1Department of Pharmacognosy and Phytochemistry, Hindu College of Pharmacy, Sonepat- 131001, Haryana, India.
Journal of Ethnopharmacology
|April 14, 2023
Summary
Acacia catechu ethanolic extract demonstrated significant antianxiety effects in mice, comparable to diazepam. This study highlights the potential of this plant extract for managing anxiety symptoms.
Area of Science:
- Pharmacology
- Ethnobotany
- Phytochemistry
Background:
- Anxiety is a prevalent psychiatric condition affecting a significant portion of the global population.
- The Acacia genus, rich in phenolic and flavonoid compounds, has a history of traditional medicinal uses.
- Previous research indicates the Acacia genus possesses diverse biological activities.
Purpose of the Study:
- To evaluate the anxiolytic potential of Acacia catechu and Acacia arabica.
- To investigate the efficacy of plant extracts in managing anxiety-related symptoms.
Main Methods:
- Successive extraction of plant stems using various solvents (petroleum ether, chloroform, ethanol, water).
- Pharmacognostic and phytochemical analyses of extracts.
- In vivo antianxiety activity assessment in Swiss albino mice using open-field, mirror chamber, and mCPP-induced anxiety tests.
Main Results:
- Ethanol extract of Acacia catechu (400 mg/kg) exhibited antianxiety activity comparable to diazepam (2.5 mg/kg).
- Administration of Acacia catechu ethanolic extract improved levels of superoxide dismutase (SOD), catalase, and lipid peroxidation (LPO).
Conclusions:
- Acacia catechu ethanolic extract shows promising anxiolytic properties.
- The extract demonstrated dose-dependent improvement in anxiety symptoms in a murine model.
Keywords:
Acacia arabicaAcacia catechuAnxietyElevated-plus mazeLight-darkMirror chamberOpen fieldmCPPMore Related Videos
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