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Related Experiment Video

Updated: Aug 2, 2025

Discovery of Driver Genes in Colorectal HT29-derived Cancer Stem-Like Tumorspheres

Discovery of Driver Genes in Colorectal HT29-derived Cancer Stem-Like Tumorspheres

Published on: July 22, 2020

Colon cancer transcriptome.

Khatere Mokhtari¹, Maryam Peymani², Mohsen Rashidi³

¹Department of Modern Biology, ACECR Institute of Higher Education (Isfahan Branch), Isfahan, Iran.

Progress in Biophysics and Molecular Biology

|April 14, 2023

Summary

This review explores how transcriptome profiling, using RNA sequencing (RNA-seq), aids in understanding colon cancer complexity. It highlights transcriptome

Keywords:

Age Alcohol Colon cancer Gender Race Stage Transcriptome circRNA lncRNA miRNA siRNA

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Area of Science:

Oncology and Molecular Biology
Genomics and Bioinformatics

Background:

Transcriptome profiling has evolved significantly over four decades.
RNA sequencing (RNA-seq) enables quantification of cellular transcriptional outputs.
Transcriptomes link cellular behavior to molecular mechanisms, crucial for cancer research.

Purpose of the Study:

To review the assessment of the colon cancer transcriptome.
To analyze transcriptome data in relation to risk factors and cancer stages.
To examine the role of non-coding RNAs in colorectal cancer.

Main Methods:

Review of existing literature on transcriptome profiling in colon cancer.
Analysis of RNA sequencing (RNA-seq) data.
Assessment of non-coding RNAs (circRNAs, miRNAs, lncRNAs, siRNAs).

Main Results:

Transcriptome analysis provides insights into tumor complexity and heterogeneity.
Risk factors (age, obesity, gender, alcohol, race) and cancer stages are associated with transcriptome changes.
Non-coding RNAs play a significant role in colorectal cancer transcriptomes.

Conclusions:

Transcriptome profiling is vital for early and accurate cancer diagnosis.
Integrating genomic and transcriptomic data offers a comprehensive view of cancer.
Understanding the colon cancer transcriptome can lead to novel biomarkers and improved treatment strategies.