Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Extracellular Matrix01:29

The Extracellular Matrix

9.2K
Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
9.2K
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

4.9K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
4.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Liquid Metal Fiber Tactile Sensors with Dual-Mechanism Enhancement of Gradient Porosity and Interfacial Polarization for Textile-Integrated Human-Machine Interaction.

ACS applied materials & interfaces·2026
Same author

Recent advances in the extraction and skincare applications of grape by-product extracts.

Nanoscale·2026
Same author

Lotus-Leaf-Extract-Based Nanoformulation for Sensitive Skin: Whitening and Barrier-Supporting Properties.

ACS applied bio materials·2026
Same author

Recent progress in targeted membrane protein degradation technology based on aptamers for disease treatment.

Biomaterials science·2025
Same author

Decalcified bone scaffold with dynamic matrix stiffness prepared by mineralization improves bone defect repair.

Biomedical materials (Bristol, England)·2025
Same author

Liquid metal based electroconductive artificial periosteum boosts bone regeneration.

Journal of biomaterials science. Polymer edition·2025

Related Experiment Video

Updated: Aug 2, 2025

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

9.8K

Hybrid Cell Membrane-Functionalized Matrixes for Modulating Inflammatory Microenvironment and Improving Bone Defect

Fangyu Qiao1, Yonggang Lv2

  • 1Mechanobiology and Regenerative Medicine Laboratory, Bioengineering College, Chongqing University, Chongqing, 400044, P. R. China.

Advanced Healthcare Materials
|April 14, 2023
PubMed
Summary

This study developed novel cell membrane-functionalized matrixes (MFMs) for bone repair. MFMs effectively reduced inflammation and promoted bone regeneration by modulating macrophage behavior and supporting mesenchymal stem cell differentiation.

Keywords:
bone repaircell membrane-functionalized matrixeselectrospinninghybrid membraneinflammation

More Related Videos

Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration
06:05

Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration

Published on: July 14, 2023

1.1K
Engineering a Bilayered Hydrogel to Control ASC Differentiation
07:48

Engineering a Bilayered Hydrogel to Control ASC Differentiation

Published on: May 25, 2012

14.0K

Related Experiment Videos

Last Updated: Aug 2, 2025

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

9.8K
Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration
06:05

Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration

Published on: July 14, 2023

1.1K
Engineering a Bilayered Hydrogel to Control ASC Differentiation
07:48

Engineering a Bilayered Hydrogel to Control ASC Differentiation

Published on: May 25, 2012

14.0K

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Cell membranes preserve structure and protein function, offering potential for bone defect repair.
  • The diverse functions of membrane proteins are currently underutilized in bone regeneration strategies.

Purpose of the Study:

  • To prepare and evaluate cell membrane-functionalized matrixes (MFMs) for enhanced bone defect repair.
  • To investigate the immunomodulatory and osteogenic effects of MFMs in vitro and in vivo.

Main Methods:

  • Hybrid membranes (HM) were prepared and coated onto poly-ε-caprolactone (PCL) electrospinning membranes to create MFMs.
  • In vitro studies assessed macrophage phenotype regulation and mesenchymal stem cell (MSC) responses (alkaline phosphatase secretion, mineralization).
  • In vivo studies evaluated MFMs in a rat calvarial critical-size defect model to assess foreign body response and bone regeneration.

Main Results:

  • MFMs successfully modulated macrophages towards an anti-inflammatory phenotype.
  • MFMs promoted alkaline phosphatase secretion and mineralization deposition in MSCs.
  • In vivo, MFMs alleviated foreign body response and facilitated bone regeneration in rat calvarial defects.

Conclusions:

  • MFMs represent an innovative approach utilizing diverse cell membrane functions for immunomodulation and osteogenic differentiation.
  • This study offers a promising strategy for designing advanced bone repair materials.