Effect of glutaurine on sleep-wakefulness cycle and aggressive behaviour in the cat

The effects of glutaurine (gamma-L-glutamyl taurine, Litoralon, Chinoin, Budapest) on the aggressive behaviour and sleep-wakefulness cycle were studied in freely moving cats. Glutaurine, even in doses as low as 0.1 microgram/kg, was found significantly to shorten the latency of the rat-killing reaction elicited by hypothalamic stimulation. On the other hand, the same doses failed to modify the sleep-wakefulness cycle to any significant degree throughout the study period of 4 hours. On the grounds of these and previous data, the possible brain site of the glutaurine action is discussed.