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Pulmonary manifestations in VEXAS syndrome

Marta Casal Moura1, Misbah Baqir1, Yasmeen K Tandon2

  • 1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.

Respiratory Medicine
|April 16, 2023
PubMed
Summary

Vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) syndrome, caused by UBA1 gene mutations, presents with common pulmonary symptoms. Treatment involves glucocorticoids, with some patients benefiting from tocilizumab or JAK inhibitors.

Keywords:
AutoinflammatoryGround glass opacitiesSomatic mutationsUBA1 geneVEXAS

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