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Updated: Aug 2, 2025

Author Spotlight: Engineering Molecular Tools for Disease Detection and Imaging
Published on: December 8, 2023
Tetralactam macrocycle based indicator displacement assay for colorimetric and fluorometric dual-mode detection of
Huan Yao1, Shi-Yao Li1, Hong Zhang2
1School of Pharmaceutical Science, Postdoctoral Research Station of Basic Medicine, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China. yanglp@usc.edu.cn.
Abstract:
An indicator displacement assay for colorimetric and fluorometric dual-mode detection of urinary uric acid (UA) was constructed using a water-soluble naphthalene-based tetralactam macrocycle and the phenoxazine dye, resorufin (RF). The visual detection of UA levels of volunteers was successfully realized using modified paper assays, which could be used for the home monitoring of urinary UA.
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