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Updated: Aug 2, 2025

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
Best Practice Recommendations for Stroke Vascular Imaging During Iodinated Contrast Shortage
Rohini Bhole1, Nina J Solenski1, Joseph H Donahue1
1Departments of Neurology (RB, NJS, NNR, SNC, BBW, AMS), Radiology and Medical Imaging (JHD, AJE, SHP, SM) and Neurosurgery (RTK, MSP), University of Virginia, Charlottesville.
A global shortage of iodinated contrast agents impacted stroke care. Hospitals revised protocols, establishing new guidelines for imaging techniques like CT angiography to ensure continued high-quality stroke treatment.
Area of Science:
- Neurology
- Radiology
- Healthcare Supply Chain Management
Background:
- A COVID-19 outbreak in Shanghai caused a temporary shutdown of a major iodinated contrast agent factory.
- This resulted in a worldwide shortage of essential contrast agents, including Omnipaque and Visipaque.
- The shortage significantly impacted healthcare providers, including Comprehensive Stroke Centers.
Purpose of the Study:
- To describe the impact of the iodinated contrast agent shortage on stroke care.
- To propose best practice recommendations for managing such shortages.
- To provide a blueprint for other hospital systems facing supply chain disruptions.
Main Methods:
- Formation of a multidisciplinary working group (vascular neurology, diagnostic neuroradiology, neurovascular surgery).
- Revision of protocols and development of local guidelines for imaging modalities.
- Focus on CT angiography, CT perfusion, and digital subtraction angiography for stroke patients.
Main Results:
- Established parameters and local guidelines to mitigate the contrast agent shortage.
- Demonstrated the ability to adapt and maintain high-quality stroke care despite supply chain issues.
- Developed a framework for managing future medical supply shortages.
Conclusions:
- The developed recommendations can serve as a blueprint for other institutions.
- Proactive protocol revision is crucial for maintaining patient care during supply chain disruptions.
- Multidisciplinary collaboration is key to effectively navigating medical supply shortages.
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