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Rat endogenous pyrogen and fever.

A Morimoto, T Watanabe, T Ono

    The American Journal of Physiology
    |May 1, 1986
    PubMed
    Summary
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    Rat endogenous pyrogen (EP) causes fever. While rat EP shows slower fever onset than human or rabbit EP, it induces similar temperature increases, with rats exhibiting faster fever responses than rabbits.

    Area of Science:

    • Immunology and Physiology
    • Fever and Pyrogen Research

    Background:

    • Endogenous pyrogens (EPs) are crucial mediators of fever.
    • Understanding interspecies differences in EP response is vital for research.

    Purpose of the Study:

    • To investigate and compare the febrile responses induced by human, rabbit, and rat endogenous pyrogens (EPs) in rabbits and rats.
    • To elucidate species-specific differences in fever induction and characteristics.

    Main Methods:

    • Preparation of rat endogenous pyrogen (EP) from lipopolysaccharide-stimulated rat white blood cells.
    • Administration of human, rabbit, and rat EPs to rabbits and rats to monitor body temperature changes.
    • Analysis of fever onset latency, time to peak fever, maximum temperature elevation, and threshold dosage.

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    Main Results:

    • Rat EP induced a significantly longer latency to fever onset and time to peak fever compared to human and rabbit EPs in both species.
    • Maximum body temperature elevation was comparable across all tested EPs.
    • Rats exhibited approximately half the latency, time to peak, and maximum fever elevation compared to rabbits, with a higher threshold dosage required for fever induction in rats.

    Conclusions:

    • Rat endogenous pyrogen (EP) can be effectively prepared using in vitro techniques.
    • Rats possess physiological mechanisms for fever development via EP production.
    • Significant interspecies differences exist in febrile responses to endogenous pyrogens.