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The first 3D-bioprinted personalized active bone to repair bone defects: A case report
Yongqiang Hao1,2,3, Bojun Cao1,2,3, Liang Deng1,2,3
1Clinical and Translational Research Center for 3D Printing Technology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
International Journal of Bioprinting
|April 17, 2023
Summary
Personalized 3D bioprinted bone implants using patient
Area of Science:
- Orthopedic surgery
- Biomaterials science
- Regenerative medicine
Background:
- Bone defect repair remains a significant orthopedic challenge.
- 3D bioprinting offers a novel approach for creating active bone implants.
Observation:
- A personalized scaffold was fabricated using autologous platelet-rich plasma (PRP) and a polycaprolactone/β-tricalcium phosphate (PCL/β-TCP) composite.
- This PCL/β-TCP/PRP scaffold was created using 3D bioprinting technology.
- The scaffold was successfully implanted for bone defect reconstruction after tibial tumor resection.
Findings:
- The 3D-bioprinted scaffold demonstrated biological activity and osteoinductivity.
- Personalized design ensures a tailored fit for the patient's specific defect.
Implications:
- 3D bioprinted active bone implants show promise for clinical applications in bone defect repair.
- This technology offers advantages over traditional bone graft materials, including enhanced biological integration and patient-specific solutions.
