Enhanced osteogenesis and bactericidal performance with additively manufactured MgO and Cu-added CpTi for...

Titanium, being the ultimate choice of metallic material for implant applications, its bio-inertness causes delayed bone-tissue integration at the implant site and prevents expedited healing for the patient. This can cause a severe issue for patients with immunocompromised bone health. Infections at the implant site are another concern; titanium does not offer inherent antimicrobial properties. Current strategies addressing the issues above include using cemented implants as a coating on Ti6Al4V bulk material for orthopedic applications. Roadblock arises with coating failure due to weak interfacial bond at the Ti-cement interface, resulting in revision surgeries. We have added osteogenic MgO and antibacterial Cu to CpTi and processed them using metal additive manufacturing (AM) to address these issues. Mg, an essential trace element in the body, has been proven to enhance osseointegration in vivo. Cu has been popular for its bactericidal capabilities. With 1 wt.% of MgO addition in the CpTi matrix, we have observed a four-fold increase in the mineralized bone formation at the bone-implant interface in vivo. The presence of 3 wt.% of Cu showed no cytotoxicity markers, and adding Cu to CpTi-MgO chemical makeup showed similar in vivo performance to CpTi-MgO. In vitro bacterial studies with gram-positive Staphylococcus aureus bacteria showed 81% bacterial efficiency displayed by CpTi-MgO-Cu at the end of 72 h of culture. Our findings highlight the synergistic benefits of CpTi-MgO-Cu, which exhibit superior early-stage osseointegration and antimicrobial capabilities.