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The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
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Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
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2-Octylcyclopentanone Inhibits Beta Lactam Resistant Diabetic Wound Pathogens.

Nur Amiera Syuhada Rozman1, Tong Woei Yenn1,2, Leong Chean Ring1

  • 1Universiti Kuala Lumpur, Branch Campus Malaysian Institute of Chemical and Bioengineering Technology, Lot 1988 Kawasan Perindustrian Bandar Vendor, Taboh Naning, 78000 Alor Gajah, Melaka, Malaysia.

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|April 17, 2023
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Summary

A novel ketone derivative, 2-octylcyclopentanone, demonstrates broad-spectrum antimicrobial activity against diabetic wound pathogens. This compound shows promise as a safe and effective alternative treatment for diabetic foot ulcer infections, particularly against resistant strains.

Keywords:
2-OctylcyclopentanoneAktiviti AntimikrobialAntimicrobial ActivityBeta Lactam ResistanceDiabetic Foot UlcerDiabetic Wound InfectionJangkitan Luka DiabetesKetahanan Beta LaktamUlser Kaki Diabetes

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Area of Science:

  • Microbiology
  • Medicinal Chemistry
  • Infectious Diseases

Background:

  • Diabetic foot ulcers frequently suffer microbial infections, affecting up to 82% of patients.
  • Rising antibiotic resistance, especially to beta-lactam antibiotics, limits treatment options and increases amputation/mortality rates.

Purpose of the Study:

  • To evaluate the antimicrobial efficacy of 2-octylcyclopentanone against common diabetic wound pathogens.
  • To assess its potential as an alternative therapeutic agent for infected diabetic foot ulcers.

Main Methods:

  • Antimicrobial activity was assessed using disc diffusion and broth microdilution assays.
  • Minimal lethality concentration and kill curve analyses were performed to determine efficacy and killing kinetics.
  • Comparative analysis against standard antibiotics was conducted.

Main Results:

  • 2-octylcyclopentanone exhibited broad-spectrum antimicrobial activity, notably against beta-lactam resistant pathogens.
  • It demonstrated superior or comparable activity to reference antibiotics like chloramphenicol, streptomycin, ampicillin, and penicillin.
  • The compound effectively inhibited a clinically isolated, multi-drug resistant *Pseudomonas aeruginosa* and showed microbicidal activity against MRSA, *P. aeruginosa*, and *Candida utilis*.
  • Killing efficiency was concentration-dependent, achieving 99.9% bacterial growth reduction.

Conclusions:

  • 2-octylcyclopentanone possesses significant antimicrobial properties against a wide range of diabetic wound pathogens.
  • Its efficacy against resistant strains suggests potential as a novel therapeutic agent for diabetic ulcer infections.
  • Further research may establish 2-octylcyclopentanone as a safe and effective alternative treatment option.