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Assays for the Identification of Novel Antivirals against Bluetongue Virus
Published on: October 11, 2013
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VITAS, a sensitive in vivo selection assay to discover enzymes producing antiviral natural products
Aws Fahd Alharbi1, Hayun Kim1, Dhirish Chumroo1
1Institute of Pharmaceutical Science, King's College London, London, UK. Kourosh.ebrahimi@kcl.ac.uk.
Abstract:
To discover new broad-spectrum antiviral nucleotide analogues from natural resources or through protein engineering, we have developed a sensitive in vivo selection assay named Viral polymerase-Inhibition Toxin-Associated Selection (VITAS). We show that the assay works with enzymes from three Kingdoms of life.

