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Clozapine Use for Bipolar Disorder: An Asian Psychotropic Prescription Patterns Consortium Study.
Lek Wei Javier Loo1, Qian Hui Chew2, Shih-Ku Lin
1From the Lee Kong Chian School of Medicine, Nanyang Technological University.
Journal of Clinical Psychopharmacology
|April 17, 2023
Summary
Clozapine was used in 2.13% of bipolar disorder patients in Asia, primarily older males with mania. This highlights the need for careful monitoring in personalized treatment plans.
Area of Science:
- Psychiatry
- Pharmacology
- Epidemiology
Background:
- Pharmacoepidemiological data on clozapine for bipolar disorder (BD) in Asia are scarce.
- Understanding clozapine use patterns in Asia is crucial for international comparisons.
- Asian Prescription Patterns Research Consortium facilitates such studies.
Purpose of the Study:
- To investigate the prevalence and clinical correlates of clozapine treatment for BD across 13 Asian countries.
- To compare clinical characteristics of BD patients receiving clozapine versus those not treated with it.
Main Methods:
- Utilized data from the Asian Prescription Patterns Research Consortium.
- Examined 13 Asian countries and regions.
- Employed bivariate comparisons and multivariable logistic regression.
Main Results:
- Clozapine was prescribed to 2.13% of BD patients at a mean daily dose of 275 chlorpromazine-equivalent mg.
- Patients on clozapine were older, more likely male, hospitalized, manic, and on multiple other psychotropic medications.
- Older age, male sex, current mania, and polypharmacy with other antipsychotics were significantly associated with clozapine use.
Conclusions:
- Specific clinical features are associated with clozapine use in bipolar disorder patients in Asia.
- Vigilance in personalized clinical monitoring is essential.
- Optimizing outcomes and minimizing risks of polytherapy are key considerations.
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