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Iatrogenic copper deficiency: Risks and cautions with zinc prescribing.

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British Journal of Clinical Pharmacology
|April 18, 2023
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Summary

Zinc-induced copper deficiency is a frequently missed diagnosis. This study found 50% of diagnosed cases were previously undiagnosed, highlighting the need for revised zinc prescription guidelines.

Keywords:
copperdeficiencyzinc

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Area of Science:

  • Clinical Medicine
  • Trace Element Metabolism
  • Nutritional Science

Background:

  • High-dose zinc supplementation can lead to copper deficiency, a condition often overlooked.
  • Zinc-induced copper deficiency (ZICD) can cause significant neurological and hematological issues.

Purpose of the Study:

  • To determine the frequency of missed diagnoses of zinc-induced copper deficiency.
  • To increase awareness of ZICD and advocate for prescribing guidelines.

Main Methods:

  • Retrospective analysis of patients with hyperzincemia and hypocupruria from the Scottish Trace Element Laboratory database.
  • Review of case records to confirm ZICD diagnosis.

Main Results:

  • 23 cases with high serum zinc and low serum copper were identified.
  • 14 patients were diagnosed with ZICD, with 7 (50%) being previously undiagnosed.

Conclusions:

  • The majority of ZICD cases remain undiagnosed due to infrequent monitoring of serum zinc and copper levels.
  • Recommendations are made to revise official advice on zinc dosage and frequency to prevent ZICD.