Third trimester physiological hypercortisolemia may protect from postpartum depression and stress
A Yavuz1, G N Kücükbas, Y Hacioglu
1Department of Obstetrics and Gynecology, University of Health Sciences, Derince Training and Research Hospital, Kocaeli, Turkey. nazkuc@gmail.com.
European Review for Medical and Pharmacological Sciences
|April 18, 2023
Summary
Higher cortisol levels in late pregnancy are linked to reduced postpartum stress and depression. This suggests cortisol may offer protective effects, aiding mothers in managing postpartum challenges.
Area of Science:
- Endocrinology
- Psychiatry
- Reproductive Health
Background:
- Cortisol plays a crucial role in the stress response.
- Pregnancy and postpartum are periods of significant physiological and psychological change.
- Understanding hormonal influences on maternal mental health is vital.
Purpose of the Study:
- To investigate the relationship between cortisol levels during late pregnancy and mood changes in the postpartum period.
- To assess the impact of free cortisol (FC) and free cortisol index (FCI) on maternal stress, anxiety, and depression.
Main Methods:
- Prospective evaluation of 77 healthy pregnant subjects at late gestation (36 weeks) and postpartum (3-4 weeks).
- Measurement of serum cortisol levels to calculate free cortisol (FC) and free cortisol index (FCI).
- Assessment of depression, anxiety, and stress using validated questionnaires (Beck Depression Inventory, Beck Anxiety Inventory, Perceived Stress Scale).
Main Results:
- Higher free cortisol (FC) levels in late pregnancy correlated with lower postpartum stress and depression scores.
- An increasing free cortisol index (FCI) during late pregnancy was associated with decreased postpartum stress and depression.
Conclusions:
- Elevated cortisol levels in late pregnancy may confer protective effects against postpartum mood disturbances.
- These findings suggest a potential role for cortisol in enhancing maternal coping mechanisms during the demanding postpartum period.
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