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Updated: Aug 2, 2025

Implementation of a Reference Interferometer for Nanodetection

Implementation of a Reference Interferometer for Nanodetection

Published on: April 26, 2014

Lab-in-a-fiber-based integrated particle separation and counting.

T Kumar¹, A V Harish², S Etcheverry³

¹Division of Nanobiotechnology, Department of Protein Science, Science for life laboratory, KTH Royal Institute of Technology, Solna, Sweden. aman@kth.se.

|April 18, 2023

Summary

This summary is machine-generated.

This study introduces an all-fiber device for particle separation and counting. It achieves high efficiency in separating 1 μm and 10 μm particles using elasto-inertial microfluidics.

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Area of Science:

Microfluidics and particle manipulation
Biomedical engineering and instrumentation

Background:

Accurate particle separation and counting are crucial for biomedical applications.
Existing microfluidic devices often face limitations in throughput and integration.

Purpose of the Study:

To develop an all-fiber integrated device for passive particle separation and counting.
To demonstrate size-based elasto-inertial separation in a continuous flow system.
To enable high-throughput particle quantification for microflow cytometers.

Main Methods:

Fabrication of an all-fiber component using silica fiber capillaries with varying diameters and cavities.
Utilizing elasto-inertial forces in a viscoelastic fluid (polyethylene oxide) for particle separation.
Employing fluorescent particles (1 μm and 10 μm) for experimental validation.
Integrating a secondary all-fiber component for particle counting.

Main Results:

Achieved 100% separation efficiency for 10 μm particles and 97% for 1 μm particles.
Demonstrated effective inertial-based separation in circular microchannels, a novel approach.
Attained a particle counting throughput of approximately 1400 particles per minute.
Successfully integrated separation and counting functionalities within an all-fiber system.

Conclusions:

The developed all-fiber device offers a promising solution for high-throughput particle separation and quantification.
This technology has the potential to advance the development of microflow cytometers for biomedical diagnostics.
The elasto-inertial separation in circular microchannels represents a significant advancement in microfluidic particle manipulation.