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CTLA4 prohibits T cells from cross-dressing
Noémie Paillon1,2,3, Claire Hivroz1,2
1Institut Curie , Paris Sciences et Lettres University, Inserm U932, Immunity and Cancer , Paris, France.
The Journal of Experimental Medicine
|April 18, 2023
Abstract:
In this issue of JEM, Xiaozheng Xu et al. (2023. J. Exp. Med.https://doi.org/10.1084/jem.20221391) report that the inhibitory protein CTLA4 internalizes in cis the B7 stimulatory molecules previously "gnawed" by T cells from antigen-presenting cells (APCs) and in doing so prevents stimulatory T-T interactions.
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