Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Aug 2, 2025

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids
08:22

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids

Published on: August 11, 2017

15.9K

Interfacial Polyelectrolyte Complexation-Inspired Bioprinting of Vascular Constructs.

Chixuan Liu1, Yen Wah Tong1

  • 1Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117585.

ACS Applied Materials & Interfaces
|April 18, 2023
PubMed
Summary

This study introduces a novel bioprinting technique using interfacial polyelectrolyte complexation for efficient blood vessel fabrication. The method utilizes hyaluronate and peptide amphiphiles with endothelial cells to create vascular constructs, advancing regenerative medicine.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Interface-Engineered Methanogenic Nanobiohybrids Redirect Hydrogen Flux for Efficient CO<sub>2</sub> Fixation.

Environmental science & technology·2026
Same author

Facile and Rapid Preparation of Injectable Collagen Hydrogel Mediated by EGCG Physical Crosslinking.

Biomacromolecules·2025
Same author

Synergetic anaerobic digestion of food waste for enhanced production of biogas and value-added products: strategies, challenges, and techno-economic analysis.

Critical reviews in biotechnology·2023
Same author

Porous organic cages as synthetic water channels.

Nature communications·2020
Same author

Toward a Better Understanding of the Nature-Inspired Aquaporin Biomimetic Membrane.

Langmuir : the ACS journal of surfaces and colloids·2019
Same author

A macromolecular approach to eradicate multidrug resistant bacterial infections while mitigating drug resistance onset.

Nature communications·2018

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Bioprinting enables layer-by-layer fabrication of 3D biological constructs using biomaterials, cells, and growth factors.
  • Current bioprinting applications are limited by the absence of efficient blood vessel fabrication techniques.
  • Vascularization remains a critical challenge for the translational success of bioprinted tissues and organs.

Purpose of the Study:

  • To develop an efficient bioprinting technique for fabricating functional blood vessel constructs.
  • To investigate the phenomenon of interfacial polyelectrolyte complexation for vascular bioprinting.
  • To explore the impact of peptide sequencing on the biocompatibility of novel bioprinting materials.

Main Methods:

  • Systematic investigation of interfacial polyelectrolyte complexation for bioprinting.
Keywords:
bioprintinghyaluronatepeptide amphiphilespolyelectrolytepolyelectrolyte complexationsupramoleculesvasculature

More Related Videos

Fabrication of Engineered Vascular Flaps Using 3D Printing Technologies
08:31

Fabrication of Engineered Vascular Flaps Using 3D Printing Technologies

Published on: May 19, 2022

3.9K
Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink
08:34

Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink

Published on: April 21, 2016

16.8K

Related Experiment Videos

Last Updated: Aug 2, 2025

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids
08:22

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids

Published on: August 11, 2017

15.9K
Fabrication of Engineered Vascular Flaps Using 3D Printing Technologies
08:31

Fabrication of Engineered Vascular Flaps Using 3D Printing Technologies

Published on: May 19, 2022

3.9K
Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink
08:34

Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink

Published on: April 21, 2016

16.8K
  • Concentric bioprinting of anionic hyaluronate and cationic lysine-based peptide amphiphiles with human umbilical endothelial cells.
  • Fabrication of tubular biological constructs with vascular features.

    • Main Results:

    • Successful development of an efficient blood vessel bioprinting technique based on interfacial polyelectrolyte complexation.
    • Fabricated tubular constructs exhibited clear vascular features, closely resembling native blood vessels.
    • Demonstrated, for the first time, the effect of peptide sequencing on the biocompatibility of the polyelectrolyte-peptide amphiphile complex for optimized bioactivity.

    Conclusions:

    • The proposed bioprinting technique offers an efficient solution for fabricating vascular structures.
    • The findings contribute to overcoming limitations in translational bioprinting applications, particularly in vascular tissue engineering.
    • Further research into peptide sequencing can optimize biomaterial design for enhanced biocompatibility and therapeutic efficacy.