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Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
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Using Synthetic Biology to Engineer Living Cells That Interface with Programmable Materials
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Functional Synthetic Biology.

Ibrahim Aldulijan1, Jacob Beal2, Sonja Billerbeck3

  • 1Systems Engineering, Stevens Institute of Technology, 1 Castle Point Terrace, Hoboken, 07030, NJ, USA.

Synthetic Biology (Oxford, England)
|April 19, 2023
PubMed
Summary
This summary is machine-generated.

Synthetic biology advances modular genetic assembly but entangles sequence and function. Functional Synthetic Biology decouples these, focusing on function for greater flexibility, predictability, and reuse in biological engineering.

Keywords:
CollaborationDesignEngineeringReproducibilitySynthetic Biology

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Area of Science:

  • Synthetic Biology
  • Genetic Engineering
  • Systems Biology

Background:

  • Significant progress in modular genetic sequence assembly and engineering biological systems.
  • Current synthetic biology paradigms inextricably link genetic sequence and biological function.
  • This linkage hinders abstraction, limits engineering flexibility, and impedes design reuse and predictability.

Purpose of the Study:

  • To introduce and advocate for a paradigm shift towards Functional Synthetic Biology.
  • To decouple the engineering of biological devices from their specific applications.
  • To enhance flexibility, predictability, and reusability in synthetic biology.

Main Methods:

  • Conceptual reorientation of synthetic biology design principles.
  • Organizational changes to support a function-centric approach.
  • Development of supporting software tools for functional design.

Main Results:

  • Enables designing biological systems based on desired function, not just sequence.
  • Facilitates abstraction and modularity in biological engineering.
  • Improves flexibility in device application and data reuse.

Conclusions:

  • Functional Synthetic Biology offers a path to overcome current limitations in the field.
  • This approach promises increased engineering flexibility, enhanced predictability, and reduced technical risk and cost.
  • Adoption of a function-first approach will accelerate innovation in synthetic biology.