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Hepatitis B virus reactivation after ibrutinib treatment

Carlos Alventosa Mateu1, Juan José Urquijo Ponce2, Armando Mena Durán3

  • 1Patología Digestiva, Consorcio Hospital General Universitario de Valencia, España.

Revista Espanola De Enfermedades Digestivas
|April 19, 2023
PubMed

New immunosuppressive and antineoplastic drugs are becoming both more numerous and more widely used, even during several years. Most of them present a low-moderate risk of hepatitis B virus (HBV) reactivation in HBsAg-negative and anti-HBc-positive patients. However, their reactivation capacity has not been clearly studied. We present the clinical case of a patient with these serological characteristics who, after 5 years of treatment with ibrutinib for chronic lymphocytic leukaemia, developed VHB reactivation, which was controlled with tenofovir. The occurrence of this event with drugs such as ibrutinib may lead to changes in HBV reactivation prophylaxis.

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