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Social and biologic determinants in lung transplant allocation.
Kara Calhoun1, Joshua Smith, Alice L Gray
1Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado School of Medicine, Denver, Colorado, USA.
Current Opinion in Organ Transplantation
|April 19, 2023
Summary
The lung allocation score (LAS) system has been updated to the composite allocation score (CAS) to address disparities in lung transplantation. The new system incorporates biologic and social factors for more equitable organ distribution.
Area of Science:
- Organ transplantation research
- Health equity studies
- Pulmonary medicine
Background:
- Lung transplantation is a critical intervention for end-stage lung disease, but donor lungs are scarce.
- The previous lung allocation score (LAS) system did not fully account for factors influencing transplant success and equity.
- Social determinants like geography and race have historically impacted transplant rates and waitlist mortality.
Conclusions:
- The transition to the CAS system represents a significant step towards more equitable lung organ allocation.
- Incorporating biologic and social determinants into allocation scores is crucial for reducing disparities in lung transplantation.
- Further evaluation of the CAS system's impact on transplant rates and outcomes across different populations is warranted.
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