Endocrinological cause behind recurrent miscarriages: primary hyperparathyroidism.

Area of Science:

• Endocrinology
• Obstetrics & Gynecology
• Reproductive Medicine

Background:

• Primary hyperparathyroidism (PHPT) is a common endocrine disorder, infrequently diagnosed during pregnancy.
• PHPT can manifest as hypercalcemia, a condition associated with an increased risk of miscarriage.
• Recurrent miscarriages may be linked to undiagnosed hypercalcemia, necessitating thorough evaluation.

Purpose of the Study:

• To highlight the importance of evaluating calcium levels in patients with recurrent miscarriages.
• To emphasize the potential benefits of early hypercalcemia detection and management in pregnancy.
• To present a case study illustrating successful management of PHPT in pregnancy.

Main Methods:

• Case report of a 39-year-old woman presenting with infertility and elevated calcium and parathyroid hormone (PTH) levels.
• Diagnostic workup included neck ultrasound to identify parathyroid adenoma.
• Treatment involved parathyroidectomy to remove the adenoma.

Main Results:

• The patient was diagnosed with PHPT due to an upper left parathyroid gland adenoma.
• Post-parathyroidectomy, serum calcium levels normalized.
• The patient subsequently achieved a successful pregnancy and delivered a healthy baby.

Conclusions:

• Routine evaluation of serum calcium levels should be considered in the management protocol for recurrent miscarriages.
• Early identification and treatment of hypercalcemia can significantly improve pregnancy outcomes.
• Prompt management of PHPT mitigates risks of pregnancy loss and associated complications.