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γδ T Cells in Skin Inflammation
Wenwu Zhang1, Abigail Pajulas1, Mark H Kaplan1
1Department of Microbiology & Immunology, Indiana University School Medicine, Indianapolis, IN 46202.
Critical Reviews in Immunology
|April 19, 2023
Summary
Gamma delta (γδ) T cells bridge innate and adaptive immunity, regulating skin homeostasis and wound healing. Understanding their immune functions offers potential for new skin disease therapeutics.
Area of Science:
- Immunology
- Dermatology
Background:
- Gamma delta (γδ) T cells are a unique T lymphocyte subset bridging innate and adaptive immunity.
- They are low in abundance (1-5% of lymphocytes) but play critical roles in peripheral tissue immune responses.
Conclusions:
- γδ T cells are key regulators of skin barrier function and wound healing.
- Their diverse immune functions highlight their significance in dermatological health.
- Targeting γδ T cells may offer novel therapeutic strategies for atopic dermatitis and psoriasis.
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