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Updated: Aug 19, 2026

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Published on: July 28, 2016
On the mechanism of AgNO3-induced lipid peroxidation in erythrocytes
Abstract:
In order to elucidate the possible mechanism of initiation of lipid peroxidation in AgNO3-treated erythrocytes, the effect of AgNO3 on hemoglobin-catalyzed peroxidation of phospholipid liposomes was studied. It was found that Ag+ significantly increases the rate of hemoglobin-catalyzed peroxidation. The inhibition of this effect by superoxide dismutase and catalase suggests that superoxide radical and H2O2 are involved. It was demonstrated also that Ag+ potentiates the hemoglobin autoxidation and increases the binding of hemoglobin to the erythrocyte membrane. On the basis of these findings a possible mechanism of initiation of peroxidation in AgNO3-treated erythrocytes is discussed.
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