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Regulation of MHC class II and CD86 expression by March-I in immunity and disease
Joanna Bandola-Simon1, Paul A Roche1
1Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 USA.
Abstract:
The expression of MHC-II and CD86 on the surface of antigen-presenting cells (APCs) must be tightly regulated to foster antigen-specific CD4 T-cell activation and to prevent autoimmunity. Surface expression of these proteins is regulated by their dynamic ubiquitination by the E3 ubiquitin ligase March-I. March-I promotes turnover of peptide-MHC-II complexes on resting APCs and termination of March-I expression promotes MHC-II and CD86 surface stability. In this review, we will highlight recent studies examining March-I function in both normal and pathological conditions.
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