Increased lipid peroxide formation in the rat forebrain during kainic acid seizures

The formation of malondialdehyde, a lipid peroxidation product, was investigated by the thiobarbituric acid test in the forebrain of rats 4 h following systemic kainic acid administration. A significantly increased level of malondialdehyde was found in the treated animals as compared to controls. The increased lipid peroxide formation may be the consequence of seizure activity, induced by kainic acid and may have deleterious effects on the cell membranes.