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Related Experiment Video

Updated: Aug 2, 2025

Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans
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Exercise during chemotherapy: Friend or foe?

Melanie Potiaumpai1, Erica A Schleicher2, Ming Wang3

  • 1Department of Public Health Sciences, College of Medicine, Pennsylvania State University, Hershey, Pennsylvania, USA.

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PubMed
Summary

Exercise may improve chemotherapy completion by reducing toxicities. However, adherence to exercise regimens can impact relative dose intensity (RDI), particularly in gastrointestinal cancer patients. Careful prescription is needed to balance benefits and risks.

Keywords:
chemotherapychemotherapy completionexerciseexercise oncologyrelative dose intensity

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Area of Science:

  • Oncology
  • Exercise Science
  • Clinical Trials

Background:

  • Higher chemotherapy completion rates correlate with improved patient outcomes.
  • Exercise interventions may mitigate chemotherapy-related toxicities, potentially enhancing treatment adherence.
  • The study investigates the link between exercise adherence and relative dose intensity (RDI).

Purpose of the Study:

  • To examine the association between exercise adherence and RDI in cancer patients.
  • To identify clinical and fitness predictors of RDI.
  • To understand how exercise impacts chemotherapy dose delivery.

Main Methods:

  • Data from 105 patients in the ENACT trial were analyzed.
  • Chemotherapy records were used to assess average RDI, with 85% as a threshold for high/low RDI.
  • Logistic regression analyses explored associations between exercise adherence, fitness, and RDI.

Main Results:

  • Breast cancer patients exhibited higher RDI (89.8%) than gastrointestinal (76.8%) and pancreatic cancer patients (65.2%).
  • Increased exercise adherence in GI patients was linked to a decrease in RDI, but a 15% RDI increase was observed in metastatic GI patients with higher adherence.
  • Cancer site significantly influenced RDI, with GI and PC patients showing lower RDI compared to BC patients.

Conclusions:

  • Exercise can support chemotherapy tolerance and completion, but its impact on RDI varies by cancer type.
  • Exercise prescription requires careful consideration of cancer site and dosage to avoid negatively affecting RDI.
  • Future research should focus on cancer site, exercise dosage, and multimodal interventions to optimize supportive care.