Changes of lymphocyte subsets in smear-negative pulmonary tuberculosis
Indian Journal of Pathology & Microbiology
|April 20, 2023
Summary
Pulmonary tuberculosis (PTB) patients show distinct immune profiles. Smear-positive PTB involves higher CD4+ T-cells and NK cells, while smear-negative PTB indicates increased B-cells and milder inflammation.
Area of Science:
- Immunology
- Infectious Diseases
- Pulmonology
Background:
- The host immune system is crucial in Mycobacterium tuberculosis (Mtb) pathogenesis and defense.
- Understanding immune system variations in different forms of pulmonary tuberculosis (PTB) is essential.
Purpose of the Study:
- To investigate immune system differences between smear-negative and smear-positive PTB patients.
- To correlate immune cell profiles with disease presentation.
Main Methods:
- Enrolled 85 active PTB patients and 50 healthy controls.
- Categorized participants into smear-negative PTB, smear-positive PTB, and control groups.
- Assessed chest computed tomography (CT) and peripheral blood lymphocyte subgroups.
Main Results:
- Smear-positive PTB patients exhibited elevated CD4+ T-cells and NK cells.
- Increased B-cell counts were observed in smear-negative PTB patients.
- Higher prevalence of pulmonary cavities was noted in the smear-positive group.
Conclusions:
- Smear-negative PTB is characterized by fewer cavities, reduced immune cell counts, and a mild inflammatory response.
- Smear-negative PTB shows a distinct immune signature with increased B-cells.
- Immune cell profiling can differentiate PTB subtypes.
Keywords:
Lymphocyte subsetsmycobacterium tuberculosispulmonary tuberculosissmear-negativesmear-positiveMore Related Videos
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