Related Experiment Video

Updated: Jun 2, 2026

Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology
08:01

Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology

Published on: March 22, 2012

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Salvage Treatment for Invasive Aspergillosis and Mucormycosis: Challenges, Recommendations and Future Considerations

Matthias Egger1,2, Romuald Bellmann3, Robert Krause1,2

  • 1Division of Infectious Diseases, Department of Internal Medicine, Medical University of Graz, Graz, Austria.

Infection and Drug Resistance
|April 20, 2023
PubMed

Insights

Salvage therapy for invasive mold diseases is challenging due to limited antifungal options. Novel antifungals in development offer future hope for combination or monotherapy treatments.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Pharmacology

Background:

  • Invasive mold diseases require careful antifungal drug management.
  • Treatment failure can occur due to drug properties, pathogen resistance, or host intolerance.
  • Adapting antifungal therapy is challenging with limited drug classes.

Purpose of the Study:

  • To outline current recommendations for salvage therapy in invasive mold diseases.
  • To discuss pharmacokinetic/pharmacodynamic (PK/PD) considerations in antifungal therapy.
  • To explore future treatment options for invasive aspergillosis and mucormycosis.

Main Methods:

  • Review of current guidelines for invasive mold disease salvage therapy.
  • Analysis of PK/PD properties influencing antifungal drug efficacy.
  • Evaluation of emerging novel antifungal agents in clinical development.

Main Results:

  • Current salvage therapy recommendations are limited and emphasize individualized approaches.
  • PK/PD factors significantly impact antifungal treatment outcomes.
  • Novel antifungals show promise for future salvage therapy, potentially in combination regimens.

Conclusions:

  • Salvage therapy for invasive mold diseases remains complex due to therapeutic limitations.
  • Future advancements with novel antifungals are expected to improve treatment strategies.
  • Personalized approaches considering PK/PD and pathogen characteristics are crucial.
Keywords:
aspergillosisinvasive fungal infectionsmucormycosissalvage therapy

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