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Oxidative stress: The nexus of obesity and cognitive dysfunction in diabetes
Huimin Li1, Jing Ren1,2, Yusi Li1
1Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Abstract:
Obesity has been associated with oxidative stress. Obese patients are at increased risk for diabetic cognitive dysfunction, indicating a pathological link between obesity, oxidative stress, and diabetic cognitive dysfunction. Obesity can induce the biological process of oxidative stress by disrupting the adipose microenvironment (adipocytes, macrophages), mediating low-grade chronic inflammation, and mitochondrial dysfunction (mitochondrial division, fusion). Furthermore, oxidative stress can be implicated in insulin resistance, inflammation in neural tissues, and lipid metabolism disorders, affecting cognitive dysfunction in diabetics.
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