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Updated: Aug 2, 2025

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
Published on: February 6, 2020
Constructive On-DNA Abramov Reaction and Pudovik Reaction for DEL Synthesis
Zhaomei Sun1, Lingqian Xiao1, Yahui Chen1
1Pharmaron (Ningbo) Technology Development Co., Ltd. No. 800 Bin-Hai fourth Road, Hangzhou Bay New Zone, Ningbo, 315336 China.
Abstract:
Organophosphonic compounds are distinctive among natural products in terms of stability and mimicry. Numerous synthetic organophosphonic compounds, including pamidronic acid, fosmidromycin, and zoledronic acid, are approved drugs. DNA encoded library technology (DELT) is a well-established platform for identifying small molecule recognition to target protein of interest (POI). Therefore, it is imperative to create an efficient procedure for the on-DNA synthesis of α-hydroxy phosphonates for DEL builds.
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