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Assembly of split aptamers by dynamic pH-responsive covalent ligation
1Department of Chemistry, University of Turku, Henrikinkatu 2, 20500 Turku, Finland. pamavi@utu.fi.
Abstract:
Reversible pH-responsive N-methoxyoxazolidine formation is used to ligate split aptamer fragments. Two twice-split models and one thrice-split model of CBA (cocaine-binding aptamer) were examined. The aptamer assembly was dynamic, proportional to the substrate concentration and occurred without interfering background ligation.
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