Related Experiment Video
Updated: Aug 2, 2025
09:21
Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
12.1K
Suboptimal lipid management in patients with acute ischemic stroke
L Vandewalle1, F Duchi2, K Verhelle2
1Department of Neurology, AZ Groeninge, Pres. Kennedylaan 4, 8500 Kortrijk, Belgium; Department of Neurology, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium; Department of Neurosciences, Experimental neurology, KU Leuven - University of Leuven, Herestraat 49, 3000 Leuven, Belgium.
Clinical Neurology and Neurosurgery
|April 20, 2023
Summary
Many patients with ischemic stroke have uncontrolled LDL-cholesterol despite lipid-lowering therapy. Intensifying treatment is crucial for cardiovascular prevention and reaching LDL-cholesterol goals.
Area of Science:
- Cardiology
- Neurology
- Pharmacology
Background:
- Lipid-lowering drugs are vital for cardiovascular prevention.
- Statins are frequently underdosed or discontinued, leading to suboptimal LDL-cholesterol control and increased cardiovascular events.
Purpose of the Study:
- To assess LDL-cholesterol (LDL-C) management and lipid-lowering therapy in hospitalized patients with ischemic stroke or transient ischemic attack.
- To determine adherence to LDL-C targets based on European guidelines.
Main Methods:
- Retrospective analysis of 92 hospitalized patients with ischemic stroke/transient ischemic attack.
- Assessment of LDL-C levels and lipid-lowering therapy at admission and discharge.
- Determination of LDL-C targets based on pre-event cardiovascular risk.
Main Results:
- 75 patients (81.5%) had inadequately managed LDL-C upon admission.
- Only 8 of 21 patients on high-intensity therapy achieved their LDL-C target.
- Hospitalization led to treatment intensification for many patients, but LDL-C goals remained unmet for a significant proportion.
Conclusions:
- LDL-cholesterol management is insufficient in patients with ischemic stroke according to international guidelines.
- Optimization of lipid management and increased use of high-intensity lipid-lowering therapy are essential in clinical practice for primary and secondary prevention.
Related Concept Videos
01:26Angina IV: Management
12
IntroductionThe management of angina requires a comprehensive approach that includes pharmacological therapies, medical procedures, and lifestyle modifications.Pharmacological TherapiesAntiplatelet agents, such as aspirin, clopidogrel, prasugrel, and ticagrelor, play a pivotal role in preventing thrombus formation in patients with angina. These medications inhibit platelet aggregation and reduce the likelihood of myocardial infarction and other cardiovascular events.Anticoagulants, including...
12
01:26Atherosclerosis III: Management
16
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
16
01:23Atherosclerosis IV: Nursing Management
29
Nursing management for a patient with arteriosclerosis involves a comprehensive approach focusing on lifestyle modification, disease monitoring, education, and symptomatic care. Here is an overview of effective nursing strategies:Assessment and Monitoring: Initial and ongoing assessments are crucial. Nurses must document the patient's medical history, including any hypertension, diabetes, hyperlipidemia, and other cardiovascular diseases. Assessments also cover family history and lifestyle...
29
01:20Lipid-Lowering Drugs: Statins and Miscellaneous Agents
717
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
717
01:28Acute Coronary Syndrome IV: Interprofessional Care
17
IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
17
01:27Peripheral Artery Disease III: Interprofessional Care
14
Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
14