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Published on: May 2, 2014
Zeolitic imidazolate framework-8 encapsulating carbon nanodots and silver nanoparticles for fluorescent detection of
Zhenzhen Guo1, Jinwen Zhu2, Jian Yin2
1Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, People's Republic of China.
Abstract:
In this study, a novel fluorescent biosensor is developed for the detection of H2O2 and glucose based on Zeolitic Imidazolate Framework-8 (ZIF-8) nanocomposites. ZIF-8 encapsulating carbon nanodot (CD) exhibits bright fluorescence emission. After further loading of AgNP, the fluorescence is quenched, which is mainly based on the excited electron transfer from CD to AgNP. Besides, the excitation wavelength of CD falls within the adsorption range of AgNP, which leads to efficient inhibition of the excitation energy. The as-prepared AgNP-CD-ZIF-8 nanocomposites can be utilized as a highly sensitive platform for the analysis of H2O2 and glucose. In the presence of glucose, H2O2 can be generated by the catalysis of glucose oxidase (GOD), which induces the etching of AgNP and subsequent recovery of CD-ZIF-8 fluorescence. This "turn on" biosensor can be applied for facile and convenient quantification of H2O2. It can also be further extended to detect glucose in real samples after combining specific catalytic effect of GOD. The analytical performances are excellent, which demonstrates great potential for practical utility.
