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Updated: Aug 2, 2025

Quantification of Coenzyme A in Cells and Tissues
Published on: September 27, 2019
Discovery and functional characterisation of protein CoAlation and the antioxidant function of coenzyme A
Valeriy Filonenko1, Ivan Gout1,2
1Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, Kyiv 03680, Ukraine.
Abstract:
Coenzyme A (CoA) is an essential cofactor in all living cells which plays critical role in cellular metabolism, the regulation of gene expression and the biosynthesis of major cellular constituents. Recently, CoA was found to function as a major antioxidant in both prokaryotic and eukaryotic cells. This unconventional function of CoA is mediated by a novel post-translational modification, termed protein CoAlation. This review will highlight the history of this discovery, current knowledge, and future directions on studying molecular mechanisms of protein CoAlation and whether the antioxidant function of CoA is associated with pathologies, such as neurodegeneration and cancer.
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