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Related Concept Videos

Skin Cancer01:30

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Dermis
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The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
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A 3D Organotypic Melanoma Spheroid Skin Model
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Dermatofibrosarcoma Protuberans of the Face.

Daniel Pardo1, Danielle Scarola2, Gillian K Weston3

  • 1University of Connecticut School of Medicine, Farmington, CT, USA.

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|April 21, 2023
PubMed
Summary

Dermatofibrosarcoma protuberans (DFSP) is a rare, aggressive skin cancer. Early recognition and complete surgical removal are vital for preventing recurrence, especially in head and neck cases.

Keywords:
Fibrosarcomatouscancerdermatofibrosarcoma protuberanshead and neck

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Area of Science:

  • Oncology
  • Surgical Pathology
  • Head and Neck Surgery

Background:

  • Dermatofibrosarcoma protuberans (DFSP) is a rare, locally aggressive skin neoplasm.
  • DFSP exhibits a high rate of local recurrence but a low potential for metastasis.
  • High-grade fibrosarcomatous variants and head and neck locations are rare and linked to worse outcomes.

Purpose of the Study:

  • To emphasize the critical importance of accurate diagnosis and management of DFSP.
  • To highlight the challenges and significance of achieving tumor-free margins in DFSP.
  • To underscore the crucial role of head and neck surgery in managing this malignancy.

Main Methods:

  • Review of clinical presentation and histopathological features of DFSP.
  • Analysis of treatment outcomes, focusing on surgical margins.
  • Evaluation of prognostic factors in DFSP, particularly in head and neck cases.

Main Results:

  • Complete surgical excision with clear margins is the most significant factor for preventing DFSP recurrence.
  • Head and neck DFSP, especially high-grade variants, present unique challenges and increased risks.
  • Accurate diagnostic recognition is paramount for effective management and improved patient prognosis.

Conclusions:

  • Optimal management of DFSP hinges on achieving wide, tumor-free surgical margins.
  • Head and neck DFSP requires specialized surgical expertise due to its aggressive nature and location.
  • Timely and accurate diagnosis is essential for improving outcomes in patients with Dermatofibrosarcoma protuberans.