Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Biosynthesis of Nucleic Acids

Biosynthesis of Nucleic Acids

Nucleic acid biosynthesis is a fundamental biochemical process that produces the purine and pyrimidine nucleotides essential for DNA and RNA synthesis. This pathway maintains a balanced nucleotide pool, preventing imbalances that could jeopardize genetic integrity and cellular function. Given the crucial role of nucleotides, their synthesis is tightly regulated to ensure proper cellular homeostasis.Purine BiosynthesisThe biosynthesis of purine nucleotides begins with ribose-5-phosphate, a...

¹H NMR: Long-Range Coupling

¹H NMR: Long-Range Coupling

The coupling interactions of nuclei across four or more bonds are usually weak, with J values less than 1 Hz. While these are usually not observed in spectra, the presence of multiple bonds along the coupling pathway can result in observable long-range coupling.
In alkenes, spin information is communicated via σ–π overlap, as seen in allylic (four-bond) and homoallylic (five-bond) couplings. These coupling interactions are stronger when the σ bond is parallel to the alkene...

Regioselectivity and Stereochemistry of Hydroboration

Regioselectivity and Stereochemistry of Hydroboration

A significant aspect of hydroboration–oxidation is the regio- and stereochemical outcome of the reaction.
Hydroboration proceeds in a concerted fashion with the attack of borane on the π bond, giving a cyclic four-centered transition state. The –BH2 group is bonded to the less substituted carbon and –H to the more substituted carbon. The concerted nature requires the simultaneous addition of –H and –BH2 across the same face of the alkene giving syn...

Covalently Linked Protein Regulators

Covalently Linked Protein Regulators

Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....

Nucleic Acid Structure

Nucleic Acid Structure

The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA...

Valence Bond Theory

Valence Bond Theory

Overview of Valence Bond Theory

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Norfloxacin-NSAID Pharmaceutical Salts: Structure-Property Relationships for Enhanced Solubility and Stability.

Crystal growth & design·2026

Same author

Expansion of the Metal-Involving Noncovalent Interaction Repertoire: The Case of Pd(II) and Pt(II) Triel Bonding.

Chemphyschem : a European journal of chemical physics and physical chemistry·2026

Same author

Noncovalent Interactions in Protein-Ti Binding: Titan Bonds at Work.

The journal of physical chemistry letters·2026

Same author

Chalcogen bonding <i>vs.</i> weakly coordinating anions - a solid state study on halidoselenium cations in an oxoanionic environment.

Dalton transactions (Cambridge, England : 2003)·2026

Same author

Structural insights into heavy chalcogen polycations and their stabilization <i>via</i> (hydrogen)polysulfates.

Dalton transactions (Cambridge, England : 2003)·2026

Same author

Imidazoliumyl-substituted di- and iso-tetraphosphanes and their metal-mediated fragmentation reactions.

Chemical science·2026

Search research articles

Related Experiment Video

Updated: Aug 2, 2025

Studying Ribonucleotide Incorporation: Strand-specific Detection of Ribonucleotides in the Yeast Genome and Measuring Ribonucleotide-induced Mutagenesis

Studying Ribonucleotide Incorporation: Strand-specific Detection of Ribonucleotides in the Yeast Genome and Measuring Ribonucleotide-induced Mutagenesis

Published on: July 26, 2018

Regium-π Bonds Involving Nucleobases: Theoretical Study and Biological Implications.

Sergi Burguera¹, Antonio Frontera¹, Antonio Bauza¹

¹Department of Chemistry, Universitat de les Illes Balears, Crta. de Valldemossa km 7.5, 07122 Palma, Baleares, Spain.

Inorganic Chemistry

|April 21, 2023

Summary

This study reveals nucleobases form Regium-π bonds (RgBs) with copper, silver, and gold ions. These noncovalent interactions are crucial for understanding metal-DNA complexes in chemical biology.

More Related Videos

mRNA Interactome Capture from Plant Protoplasts

mRNA Interactome Capture from Plant Protoplasts

Published on: July 28, 2017

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids

Published on: September 21, 2017

Related Experiment Videos

Last Updated: Aug 2, 2025

Studying Ribonucleotide Incorporation: Strand-specific Detection of Ribonucleotides in the Yeast Genome and Measuring Ribonucleotide-induced Mutagenesis

Studying Ribonucleotide Incorporation: Strand-specific Detection of Ribonucleotides in the Yeast Genome and Measuring Ribonucleotide-induced Mutagenesis

Published on: July 26, 2018

mRNA Interactome Capture from Plant Protoplasts

mRNA Interactome Capture from Plant Protoplasts

Published on: July 28, 2017

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids

Published on: September 21, 2017

Area of Science:

Chemical Biology
Biophysical Chemistry
Computational Chemistry

Background:

Regium-π bonds (RgBs) are noncovalent interactions involving group 11 elements (Cu, Ag, Au) and electron-rich species.
While metal coordination to DNA bases is known, the noncovalent forces driving these interactions are less understood.

Purpose of the Study:

To provide crystallographic and theoretical evidence for nucleobase involvement in Regium-π bonds (RgBs).
To systematically analyze RgBs in metal-DNA complexes and characterize their properties.

Main Methods:

Protein Data Bank (PDB) inspection for crystallographic evidence.
Computational modeling using RI-MP2/def2-TZVP//PBE0-D3/def2-SVP.
Charge-density analysis via Atoms in Molecules (AIM) theory, NCIplot, and Natural Bonding Orbital (NBO) analyses.

Main Results:

Crystallographic and theoretical data confirm RgBs between DNA bases and Cu, Ag, and Au ions.
Computational models elucidate the strength and directionality of these noncovalent interactions.
Detailed characterization of RgB properties using advanced computational methods.

Conclusions:

This work presents the first systematic analysis of RgBs in metal-DNA complexes.
Findings offer insights into metal-nucleic acid interactions for nucleic acid engineering and chemical biology.
Aims to increase the visibility and understanding of RgBs within the biological community.