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Construction and Characterization of a Novel Vocal Fold Bioreactor
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Tissue-engineered vocal fold replacement in swine: Methods for functional and structural analysis.

Patrick Schlegel1, Kenneth Yan2, Sreenivasa Upadhyaya3,4

  • 1Department of Head and Neck Surgery, David Geffen School of Medicine at the University of California-Los Angeles, Los Angeles, California, United States of America.

Plos One
|April 21, 2023
PubMed
Summary
This summary is machine-generated.

A novel cell-based vocal fold replacement (COVR) shows promise for voice restoration. This therapy improved tissue structure and voice function in a large animal model, paving the way for further pre-clinical studies.

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Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Otolaryngology

Background:

  • Vocal fold injury, radiation, or tumor resection can impair voice quality.
  • Current treatments for vocal fold damage have limitations.
  • A cell-based regenerative approach is needed for vocal fold repair.

Purpose of the Study:

  • To develop and assess a cell-based outer vocal fold replacement (COVR) in a large animal model.
  • To evaluate the feasibility, safety, and efficacy of COVR implantation.
  • To establish methods for phonatory assessment in pigs post-implantation.

Main Methods:

  • COVR was created using human adipose-derived stem cells in a fibrin scaffold.
  • Implantation was performed in eight pigs, with tissue harvest at 2 weeks to 6 months.
  • Laryngeal tissue structure was analyzed via vibratory and histologic methods.
  • Voice function was assessed using pig-specific acoustic parameters.

Main Results:

  • COVR implantation was feasible and safe in the pig model.
  • Improved lamina propria qualities were observed at 6 months compared to controls.
  • Acoustic analysis showed initial voice worsening followed by recovery in the 6-month animal.

Conclusions:

  • The COVR shows potential as a therapy for voice restoration after vocal fold injury.
  • The developed methods support further pre-clinical safety and efficacy studies.
  • This regenerative approach holds promise for improving voice quality.