Myricetin: a potential plant-derived anticancer bioactive compound-an updated overview

Area of Science:

• Phytochemistry
• Oncology
• Pharmacology

Background:

• Conventional cancer treatments like chemotherapy and radiation cause severe side effects and drug resistance.
• Natural phytochemicals are being explored as safer, cost-effective alternatives for cancer therapy.
• Myricetin, a flavonoid found in plants, exhibits promising bioactivities for cancer prevention.

Purpose of the Study:

• To review the bioactivities and mechanisms of action of myricetin against cancer cells.
• To explore the potential of myricetin and its derivatives as anticancer agents.
• To discuss challenges and future directions for myricetin in cancer treatment.

Main Methods:

• Literature review of existing studies on myricetin's anticancer properties.
• Analysis of myricetin's effects on cellular processes involved in cancer proliferation.
• Examination of myricetin's anti-inflammatory, anticancer, and apoptosis-inducing capabilities.

Main Results:

• Myricetin demonstrates anticancer characteristics across various cancer types, including colon, breast, prostate, bladder, and pancreatic cancers.
• It possesses anti-inflammatory, anticancer, and apoptosis-inducing properties, inhibiting cancer cell proliferation.
• Myricetin and its derivatives show potential as valuable bio-agents for cancer prevention and treatment.

Conclusions:

• Myricetin is a promising plant-derived compound with significant anticancer potential.
• Its ability to impede cancer cell spread and proliferation warrants further investigation for therapeutic applications.
• Future research should focus on overcoming challenges and optimizing the use of myricetin as an anticancer drug.