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Related Experiment Video

Updated: Aug 2, 2025

Isolation of Enteric Glial Cells from the Submucosa and Lamina Propria of the Adult Mouse
07:53

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Mini-review: Intercellular communication between enteric glia and neurons.

Beatriz Thomasi1, Brian Gulbransen1

  • 1Department of Physiology, Michigan State University, USA.

Neuroscience Letters
|April 21, 2023
PubMed
Summary

The enteric nervous system (ENS) uses neuron-glia communication for digestion and gut homeostasis. Understanding these signals is key to gut function and health.

Keywords:
Enteric gliaEnteric neuronGut motor controlInflammatory bowel diseaseIntercellular signaling

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Last Updated: Aug 2, 2025

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Area of Science:

  • Neuroscience
  • Gastroenterology
  • Cellular Biology

Background:

  • The enteric nervous system (ENS) is a complex neural network within the gastrointestinal tract.
  • It regulates digestion and maintains gut homeostasis through intricate signaling pathways.
  • Interactions between enteric neurons and glia are crucial for ENS function.

Conclusions:

  • Intercellular signaling between enteric neurons and glia plays a vital role in ENS function.
  • These interactions are fundamental to digestive processes and gut health.
  • Further research into neuron-glia communication can reveal new therapeutic targets for gastrointestinal disorders.