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The "Great Debate" at Immunotherapy Bridge 2022, Naples, November 30th-December 1st, 2022
Paolo A Ascierto1, Renier Brentjens2, Samir N Khleif3
1Department of Melanoma, Cancer Immunotherapy and Innovative Therapy, Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale", Naples, Italy. paolo.ascierto@gmail.com.
Journal of Translational Medicine
|April 22, 2023
Summary
Leading experts debated key immunotherapy topics, including adoptive cell therapy for solid tumors and biomarker strategies. Audience votes reflected engagement with diverse expert viewpoints on cutting-edge cancer treatments.
Area of Science:
- Immunotherapy research and clinical applications.
Background:
- The 2022 Immunotherapy Bridge congress hosted a Great Debate session.
- This session addressed contemporary challenges and advancements in immunotherapy.
Purpose of the Study:
- To present and discuss contrasting expert opinions on critical immunotherapy topics.
- To gauge audience perception and shifts in opinion regarding these topics.
Main Methods:
- Three distinct debates were conducted, featuring leading experts presenting counterpoint views.
- Topics included the role of adoptive cell therapy (ACT) in solid tumors.
- Debates also covered peripheral/blood biomarkers versus tumor microenvironment biomarkers for cancer immunotherapy, and chimeric antigen receptor T cell versus natural killer cell therapy.
Main Results:
- Expert opinions were presented on the utility of ACT in solid tumors.
- The relative merits of peripheral/blood biomarkers versus tumor microenvironment biomarkers were debated.
- The comparative roles of chimeric antigen receptor T cell therapy and natural killer cell therapy were discussed.
Conclusions:
- The debates stimulated discussion on the evolving landscape of cancer immunotherapy.
- Audience voting before and after each debate provided insights into evolving perspectives on these complex issues.
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