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Related Concept Videos

Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

179
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
179
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

243
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
243
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

498
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
498
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

370
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
370
Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

186
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
186
Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

161
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
161

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Murine Ileocolic Bowel Resection with Primary Anastomosis
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Immune mediated colitis: a surgical perspective.

Khang Duy Ricky Le1,2,3, Kay Tai Choy4, Sara Roth5,6,7

  • 1Department of General Surgical Specialties, The Royal Melbourne Hospital, Melbourne, Victoria, Australia.

ANZ Journal of Surgery
|April 24, 2023
PubMed
Summary

This review highlights the crucial role of surgical specialties in managing immune-mediated colitis, an adverse event of cancer immunotherapy. Surgeons are increasingly needed for prompt diagnosis and multidisciplinary care of this condition.

Keywords:
checkpoint inhibitor induced colitischeckpoint inhibitorscoloncytotoxic T-lymphocyte associated antigen 4immune checkpoint inhibitorsimmune mediated colitisimmune related adverse eventsimmune therapyimmunotherapyimmunotherapy induced colitisprogrammed cell death protein 1programmed death ligand 1

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Area of Science:

  • Oncology
  • Gastroenterology
  • Surgical Specialties

Background:

  • Immune-mediated colitis is a significant adverse event associated with cancer immunotherapy.
  • Current management often mirrors inflammatory bowel disease protocols, primarily involving medical specialties.

Purpose of the Study:

  • To review and summarize current literature on immune-mediated colitis treatment.
  • To explore the role of surgical specialties in the management of immune-mediated colitis.

Main Methods:

  • A narrative review of relevant literature was conducted.
  • Literature search performed using Medline, EMBASE, and Cochrane Central databases.

Main Results:

  • Diagnosis and treatment guidelines for immune-mediated colitis are guided by oncology and gastroenterology.
  • Surgical expertise is essential for diagnosis and managing complications of immune-mediated colitis.

Conclusions:

  • Surgical involvement is critical for comprehensive immune-mediated colitis management.
  • Surgeons need to be familiar with multidisciplinary approaches for prompt diagnosis and treatment.
  • Enhanced collaboration between surgical and medical specialties is necessary for optimal patient care.