Diode Laser Irradiation Effects on Miniscrew Stability and IL-1β and TGF-β1 Levels: A Split-Mouth Randomized...

Area of Science:

• Orthodontics
• Biomaterials Science
• Laser Therapy

Background:

• Miniscrews are crucial for orthodontic anchorage, but their stability can be compromised.
• Inflammatory mediators like IL-1β and TGF-β1 play a role in the bone-implant interface.
• Low-level laser therapy (LLLT) has shown potential in modulating biological responses.

Purpose of the Study:

• To evaluate the impact of LLLT on orthodontic miniscrew stability.
• To assess LLLT's effect on interleukin-1β (IL-1β) and transforming growth factor-beta (TGF-β1) concentrations in peri-miniscrew crevicular fluid.

Main Methods:

• A randomized split-mouth double-blind clinical trial involving 18 patients.
• LLLT (980-nm wavelength, 100-mW continuous wave) applied to one quadrant; control (pseudo-application) to the other.
• Miniscrew stability measured by Periotest value (PTV); IL-1β and TGF-β1 levels analyzed in crevicular fluid.

Main Results:

• LLLT group showed significantly improved miniscrew stability (lower PTV) at 1 and 3 months.
• IL-1β concentrations were significantly lower in the LLLT group at 1 hour and 3 months post-placement.
• TGF-β1 levels showed a non-significant trend towards reduction in the LLLT group.

Conclusions:

• LLLT is effective in enhancing orthodontic miniscrew stability.
• LLLT application can decrease the concentration of the pro-inflammatory cytokine IL-1β.
• LLLT shows promise as an adjunct therapy for improving miniscrew osseointegration and stability.