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Related Experiment Videos

Non-interaction between nifedipine and digoxin.

K E Pedersen, J L Madsen, N A Klitgaard

    Danish Medical Bulletin
    |April 1, 1986
    PubMed
    Summary
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    This study found that nifedipine does not significantly alter digoxin pharmacokinetics. Coadministration of nifedipine with digoxin in healthy subjects showed no changes in plasma digoxin concentration or clearance.

    Area of Science:

    • Pharmacology
    • Clinical Pharmacology
    • Drug Interactions

    Background:

    • Digoxin is a cardiac glycoside used to treat heart failure and arrhythmias.
    • Nifedipine is a calcium channel blocker used to treat hypertension and angina.
    • Potential drug interactions between digoxin and nifedipine require investigation.

    Purpose of the Study:

    • To evaluate the pharmacokinetic interaction between digoxin and nifedipine.
    • To determine if nifedipine affects digoxin absorption, distribution, metabolism, or excretion.

    Main Methods:

    • Eight healthy subjects received oral digoxin to achieve steady-state concentrations.
    • Nifedipine was coadministered orally for two weeks.
    • Plasma digoxin concentrations, renal clearance, and urinary recovery were measured before and during nifedipine coadministration.

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    Main Results:

    • Mean plasma digoxin concentration was 0.68 ng/ml (control) vs. 0.74 ng/ml (nifedipine), a non-significant difference.
    • Nifedipine did not significantly alter renal digoxin clearance (173.6 ml/min vs. 173.1 ml/min).
    • 24-hour urinary recovery of digoxin also showed no significant change with nifedipine coadministration.

    Conclusions:

    • Nifedipine coadministration does not significantly alter digoxin pharmacokinetics in healthy subjects.
    • These findings support previous observations regarding the lack of interaction.
    • Clinicians can be reassured regarding the coadministration of these two medications.