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Updated: Aug 1, 2025

Photo-Induced Cross-Linking of Unmodified Proteins PICUP Applied to Amyloidogenic Peptides
Published on: January 12, 2009
Attenuation of α-synuclein aggregation by catalytic photo-oxygenation
Atsushi Iwai1, Reito Nakamura2, Ikumi Tomizawa2
1Laboratory of Synthetic Organic Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. kanai@mol.f.u-tokyo.ac.jp.
Abstract:
We developed catalyst 11 to promote selective photo-oxygenation of α-synuclein amyloid and attenuate its aggregation. Catalyst 11 effectively oxygenated both small and large aggregates. The oxygenated α-synuclein exhibited lower seeding activity than intact α-synuclein. This study corroborates the feasibility of catalytic photo-oxygenation as an anti-synucleinopathy strategy.

