Related Experiment Video
Updated: Aug 1, 2025

Induction and Assessment of Exertional Skeletal Muscle Damage in Humans
Published on: December 11, 2016
Eccentric Exercise as a Potent Prescription for Muscle Weakness After Joint Injury
Lindsey K Lepley1, Luke Stoneback1, Peter C D Macpherson
1School of Kinesiology, University of Michigan, Ann Arbor, MI.
Abstract:
Lengthening contractions (i.e., eccentric contractions) are capable of uniquely triggering the nervous system and signaling pathways to promote tissue health/growth. This mode of exercise may be particularly potent for patients suffering from muscle weakness after joint injury. Here we provide a novel framework for eccentric exercise as a safe, effective mode of exercise prescription for muscle recovery.
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