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Growing human-scale scala tympani-likein vitrocell constructs.

Ulises A Aregueta Robles1, Florence Bartlett-Tomasetig2, Laura A Poole-Warren1,3

  • 1Graduate school of Biomedical Engineering, University of New South Wales, Sydney, Australia.

Biofabrication
|April 24, 2023
PubMed
Summary

Researchers developed human-scale tissue models of the cochlea (inner ear) to test bionic ear devices. These 3D-printed hydrogel structures support cell growth and can accommodate cochlear implants for faster evaluation.

Keywords:
3D printing3D tissue engineeringcochlear implantsmould castingscala tympani in vitro model

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Area of Science:

  • Biomaterials Engineering
  • Tissue Engineering
  • Medical Device Development

Background:

  • Advancements in bionic devices require innovative preclinical testing methods.
  • Current preclinical and clinical studies face significant time, regulatory, and cost barriers.
  • In vitro tissue models offer a promising solution to accelerate product development.

Purpose of the Study:

  • To engineer human-scale cochlea models for high-throughput evaluation of cochlear implants.
  • To compare mould-casting and stereolithography 3D printing for creating scala tympani-like structures.
  • To develop a platform for testing cochlear implant efficacy and safety on the bench.

Main Methods:

  • Utilized novel mould-casting and stereolithography three-dimensional (3D) printing techniques.
  • Fabricated hydrogel structures mimicking the spiral morphology of the human scala tympani.
  • Assessed hydrogel structure viability for cell adhesion and cochlear implant accommodation.

Main Results:

  • Successfully developed human-scale, scala tympani-like hydrogel structures.
  • Demonstrated that these structures support viable cell adhesion.
  • Confirmed the ability of the hydrogel models to accommodate cochlear implants for testing.

Conclusions:

  • Engineered hydrogel models provide a viable platform for testing cochlear implants.
  • These in vitro models can help overcome barriers in bionic device development.
  • The developed technology facilitates high-throughput evaluation of next-generation cochlear devices.