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Anticipating social feedback involves basal forebrain and mesolimbic functional connectivity.

Alexandra Sobczak1, Mushfa Yousuf1, Nico Bunzeck2

  • 1Department of Psychology, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck, Germany.

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Summary

The basal forebrain and mesolimbic system show distinct functional connectivity patterns when anticipating social feedback. These neural pathways signal emotional valence, offering new insights into social information processing.

Keywords:
AccumbensBasal forebrainFunctional connectivityMVPASocial reward learningSubstantia nigrafMRI

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Area of Science:

  • Neuroscience
  • Social Neuroscience
  • Cognitive Neuroscience

Background:

  • The mesolimbic system and basal forebrain (BF) are crucial for processing rewards and punishments.
  • Their specific roles and interactions in anticipating social outcomes are not fully understood.

Purpose of the Study:

  • To investigate regional responses and functional connectivity within the BF and mesolimbic areas during social feedback anticipation.
  • To explore how these neural circuits process neutral, positive, and negative social feedback.

Main Methods:

  • High-resolution fMRI (1.5mm³) was used on 36 healthy humans during a social incentive delay task.
  • Analysis included mass-univariate, functional connectivity, and multivariate pattern analysis of the anticipation phase.
  • Specific brain regions studied were the Substantia Nigra (SN), Nucleus Accumbens (NAcc), Nucleus basalis of Meynert (NBM), and Medial Septum/Diagonal Band (MS/DB).

Main Results:

  • Participants exhibited faster responses anticipating positive and negative feedback compared to neutral feedback.
  • Anticipating social information engaged valence-related and unrelated functional connectivity patterns involving the BF and mesolimbic areas.
  • Specific SN subregion (lateral, ventral, medial) connectivity patterns differentiated anticipation of neutral, positive, and negative social feedback.

Conclusions:

  • Functional connectivity within the BF and mesolimbic areas dynamically signals the anticipation of social feedback based on its emotional valence.
  • These findings provide novel insights into the neural mechanisms underlying social information processing and emotional valence detection.