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Dengue and COVID-19 Co-Circulation in the Peruvian Amazon: A Population-Based Study
Maria J Pons1, Ana Mayanga-Herrera2, Gabriela M Ulloa1
1Grupo de Enfermedades Infecciosas Re-emergentes, Universidad Científica del Sur, Lima, Peru.
The American Journal of Tropical Medicine and Hygiene
|April 24, 2023
Summary
High rates of COVID-19 and dengue virus (DENV) antibodies were found in Iquitos, Peru. Despite co-circulation, no correlation was observed between antibodies for these two diseases.
Area of Science:
- Epidemiology
- Infectious Diseases
- Public Health
Background:
- The COVID-19 pandemic significantly impacted Amazonian cities, with Iquitos, Peru, showing high SARS-CoV-2 antibody seroprevalence during the initial wave.
- Concerns arose regarding the potential co-circulation of dengue virus (DENV) and SARS-CoV-2 and their combined health implications in Iquitos.
Purpose of the Study:
- To investigate the seroprevalence of anti-dengue virus (DENV) and anti-SARS-CoV-2 antibodies in adults in Iquitos, Peru.
- To explore potential correlations between DENV and SARS-CoV-2 antibody levels in the studied population.
Main Methods:
- A population-based cohort study was conducted in Iquitos, Peru, involving 326 adults.
- Serum samples were analyzed using ELISA to detect IgG antibodies against DENV (serotypes 1-4) and SARS-CoV-2 (anti-spike IgG and IgM).
Main Results:
- High seroprevalence rates were observed for both anti-SARS-CoV-2 (78.0%) and anti-DENV (88.0%) antibodies in Iquitos City.
- The San Juan District exhibited lower anti-DENV antibody seroprevalence compared to the Belen District, but no significant difference was found for anti-SARS-CoV-2 antibodies.
- No correlation was identified between the antibody levels for DENV and SARS-CoV-2.
Conclusions:
- Iquitos City experienced exceptionally high seroprevalence for both DENV and SARS-CoV-2 during the first COVID-19 wave.
- The study indicates co-circulation of these viruses but found no evidence of a link between their respective antibody levels in this population.
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