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Neurological Considerations with COVID-19 Vaccinations
Abhilasha P Boruah1,2, Kimia Heydari1, Anne E Wapniarski1
1Department of Neurology, Columbia University Irving Medical Center/New York Presbyterian Hospital (CUIMC/NYP), New York, New York.
Seminars in Neurology
|April 24, 2023
Summary
COVID-19 vaccination offers significant public health benefits, crucial for controlling SARS-CoV-2 spread. While rare adverse events are reported, evidence suggests a high neurological safety profile for approved vaccines.
Area of Science:
- Neurology
- Immunology
- Public Health
Background:
- Coronavirus disease 2019 (COVID-19) vaccination is vital for controlling SARS-CoV-2.
- Reports of adverse events following vaccination necessitate careful evaluation.
Purpose of the Study:
- To assess the evidence quality and extent of serious adverse neurological events linked to FDA-approved COVID-19 vaccines.
- Focus on BNT162b2, mRNA-1273, and Ad26.COV2.S vaccines.
Main Methods:
- Literature review of five databases (PubMed, Medline, Embase, Cochrane, Google Scholar) from Dec 2020 to June 2022.
- Included systematic reviews, meta-analyses, cohort studies, case-control studies, case series, and reports.
- Excluded editorials, letters, and animal studies.
Main Results:
- 149 articles were reviewed; 97 (65%) were case reports or series.
- Three phase 3 trials for the vaccines were included.
- The evidence quality for neurological adverse events was generally low tier.
Conclusions:
- COVID-19 vaccinations demonstrate a high neurological safety profile.
- Continued monitoring of vaccination risks and benefits is essential.
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